We identify FUS immunoreactive inclusions in both sporadic ALS and familial ALS

H-X Deng, MD, PhD is the lead author of a publication in online Annals of Neurology that reports the presence of FUS immunoreactive inclusions in postmortem spinal cord tissue from patients with both sporadic and familial ALS (FALS). These findings provide a new basis for investigation of a rational therapy that may be effective for SALS and FALS.

Collaborators included Eileen Bigio, MD and Manjari Mishra, PhD of Northwestern’s Division of Neuropathology and Enrico Mugnaini MD of Northwestern’s Department of Cell and Molecular Biology.

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